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Crovell Biotech (Hebei) Co., Ltd.
Crovell Biotech (Hebei) Co., Ltd.

China Calcium Propionate 4075-81-4 Calcium Propionate 4075-81-4 manufacturer


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Calcium Propionate 4075-81-4 Calcium Propionate 4075-81-4 

Price: 5.0 USD 
Payment Terms: T/T,L/C,WU,Paypal,Money Gram 
Special Groups: Industrial Chemicals (117)
Place of Origin: Hebei, China (Mainland) 
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Product Detail

Model No.: 200
Production Capacity: 500MT/month
Delivery Date: 15 days
CAS: 4075-81-4
MW: 186.22
colour: White
Means of Transport: Ocean,Land,Air
Packing: 50kg bag
Product Name: Calcium Propionate
EINECS: 223-795-8

product name : Calcium Propionate
CAS NO: 4075-81-4
Crystals or Crystalline Powder

product  name  : Calcium Propionate   

CAS  NO:  4075-81-4                                

MF :H8N2O4S  

Crystals or Crystalline Powder

best  quality  with  lowest  price  

Email: Alice  at 

Skype: alice77889900 at 

Product Name:

Calcium Propionate









Mol File:



Calcium Propionate Chemical Properties


Melting point 

300 °C

storage temp. 

Store below +30°C.


water: soluble1g/10 mL, clear, colorless


Crystals or Crystalline Powder




9.2 (200g/l, H2O, 20℃)(IUCLID)

Water Solubility 

1 g/10 mL




Stable. Hygroscopic. Incompatible with strong oxidizing agents.

CAS DataBase Reference

4075-81-4(CAS DataBase Reference)

EPA Substance Registry System

Propanoic ac , calcium salt(4075-81-4)


Safety Information


Risk Statements 


Safety Statements 


WGK Germany 






Hazardous Substances Data

4075-81-4(Hazardous Substances Data)



Calcium Propionate Usage And Synthesis


Food antifungal agent

Calcium Propionate as the newer food antifungal agent, is the calcium salt of propanoic ac  which is a antifungal agent. It appears as white crystalline or powder, odorless or having slight specific odor of propionic ac , stable under light and heat , hygroscopic, soluble in water while aqueous solution is alkaline, slightly soluble in methanol and ethanol, not soluble in benzene and acetone. It is deliquescent in moist air and loses crystal water when heated to 120 ℃ .It changes phase at 200~210 ℃ and decomposes to calcium carbonate at 330~340 ℃ . Under ac ic conditions, it generates free propanoic ac  which is weaker than sorbic ac  while stronger than acetic ac , and has an antibacterial effect on Aspergillus niger and gas bacillus rather than yeast . Calcium Propionate is a normal intermediate product of animal metabolism and is safe eaten by animals. It has a broad antibacterial activity to mold bacteria and yeast bacteria, inhibiting the propagation of microorganisms, preventing feed molding, which can be used as a fungicide on food and feed and a preservative for bread and pastries. As a feed additive ,it can effectively prevent feed molding and prolong shelf life of feed . If combined with other inorganic complexes, it can also improve the appetite of livestock, increase milk production in cows, and its dosage is less than 0.3% of the combined feed (use propionic ac  to count) . China provides when it is used as a food additive, according to GB2760-86 execution, it can be added to bread, vinegar, soy sauce, soy products, and the maximum use is 2.5g/kg.

Production Method

First, the raw material calcium carbonate is made into aqueous suspension, the water needs to be refined and purified to remove heavy metals magnesium and other impurities. The CaCO3 is put in aqueous suspension into the reaction kettle quantitatively and the inner temperature is kept of 60~80 ℃, adding propionic ac  with stirring, and the reaction lasts for 2 to 3 hours, then a lot of CO2 gas escapes, which can be discharged from the condenser vent tube .Adjusting the heating temperature outside, adding ac  and stirring rate can help the reaction to achieve the best conditions , the reaction should be controlled in the final pH of 7 to 8, this reaction is reversible, which means CO2 gas should be promptly discharged to control the end point of the reaction better . The neutralized aqueous solution is filtrated through vacuum , concentrated in an evaporator vessel, and then placed in a crystallizer tank at normal temperature and pressure to cool slowly into crystallization. The mother liquor can be returned to the evaporator vessel to apply 2 or 3 times and then can be discarded. Dry the separated solids into small particles and after crushing, metering and packaging , Calcium Propionate products are obtained. 
The above information is edited by the Chemicalbook of Tian Ye.

Content Analysis

Dry the sample at 120 ℃ for 2h, take 1g (weighing accuracy of 0.0002g), dissolve it in water and transfer it to a 100ml volumetric flask, dilute to the mark. Measure 25.00ml of it, add 75ml water , titrate to the end with 0.05mol/L disodium EDTA standard solution, add 10% sodium hydroxide solution 15m !, place 1min. Add 0.1g calcium indicator reagent carboxylate (0.5g of calcium plus potassium carboxylate reagent mixing 50g), continue titration to the disappearance of the red and the appearance of the blue . 
Calcium Propionate content (%) = V × c × 74.48/m × 100 
Where V-volume of disodium EDTA standard solution, ml;
c-the concentration of disodium EDTA standard solution, mol/L;
m--sample quality , g.
Or every Ml0.05mol/L EDTA-sodium equivalent to 9.311mg of the product.

Application limitation

GB 2760-96 (g/kg): bread, vinegar, soy sauce, soy foods, pastries, 2.5; wet dough products (refer to section, wonton skin) ≤0.25 (use propionic ac  to count). 
FAO/WHO (1984): Processed cheese 3000mg/kg (alone or in combination with propionic ac , sorbic ac  and its salts ). 
Japan (use propionic ac  to count): 2.5g/kg ( the product 3.15g).It is mainly used for bread and pastry. 1.0g calcium salt (monohydrate) equals 0.790g propanoic ac  ). The excess of amount will prevent the growth of yeast in the bread, which damages the flavor. It can be used to prevent growth of Aspergillus niger (Asp.Niger), aerobic spore-forming bacteria (B.Subtilis) . 
USDA, 9CFR, §318.7 (2000): flour products, 0.32% (use wheat flour amount to count, alone or together with the amount of sodium propionate). 
USDA§381.147 (1994): The new pie dough 3% (use wheat flour amount to count).
Calcium salt is generally used in bread while sodium salt is used in West Point .Alkalinity resulting from the use of sodium causes the delaying of the dough fermentation but use of calcium can strengthen the role of calcium. If calcium salt is used in West Point, then it can react to the sodium bicarbonate in the leavening agent, producing insoluble calcium carbonate, which reduces the amount of CO2 generated,so sodium salt is mainly used .

Chemical Properties

White crystalline powder or granules. Good flowability. Odorless and minor irritation.


Reagents for the analysis. 
Calcium Propionate is an ac -type food preservative, with its inhibitory effected by the environmental pH .When PH5.0 minimum inhibitory concentration is 0.01%, PH6.5 is 0.5%. In the ac ic medium ,it has a strong inhibitory effect on the various types of fungi, aerobic bacillus or gram-negative bacilli . It has a specific effect on preventing the production of Aflatoxin streptozotocin, but has little effect on the yeast. In the food industry, it is mainly used in vinegar, soy sauce, bread, cakes and soy products,whose maximum usage (use propionic ac  to count, the same below)is 2.5g/kg; while the largest usage in the wet dough products is 0.25g/kg . Also ,it can be used for feed antifungal agent. 
It is used for breads, pastries and cheese preservatives and feed fungicide. Calcium Propionate as a food preservative, calcium propionate is mainly used for bread, because sodium propionate keeps pH of bread rising, delays the fermentation of the dough; sodium propionate is more widely used for cake, because the pastry gets bulky by using leavening agent, there is no problem about yeast development caused by tincrease in the pH . As a feed preservative, sodium propionate is better than calcium propionate. But Calcium Propionate is more stable than sodium propionate. In food industry , except uses for bread, pastries, cheese, Calcium Propionate can also be used for preventing soy sauce from getting moldy which inhibits the refermentation . In medicine, Calcium Propionate can be made into powders, solutions and ointments to treat skin disease caused by parasitic fungi. Ointment (liquid) contains 12.3% sodium propionate, while a powder contains15% Calcium Propionate.

Production method

By reacting propanoic ac  with calcium hydroxide or calcium carbonate : industry generally uses calcium hydroxide as raw materials ,makes calcium hydroxide into the suspension, adds propanoic ac , keeps the reaction temperature maintaining 70-100 ℃, after 2-3 hours' reaction, controls the end point of the reaction at Ph7-8. The product is obtained after filtering and drying the reaction mass. 
Propionic ac  neutralizes calcium hydroxide.
Make Calcium hydroxide powder into suspension in a pot , add propionic ac  to a pH 7-8, and a neutralization temperature of 70~100 ℃, and neutralization time is 2~3h. Neutralization fluid is filtered to remove insoluble material. The supernatant is concentrated, cooled and crystallized,separated, dried to obtain products. 
CH3CH2COOH [Ca (OH) 2] → (CH3CH2COO) 2Ca


Toxic substances

Toxicity grading

Middle toxic

Acute toxicity

Oral-rat LD50: 3920 mg/kg; Oral-Mouse LD50: 2350 mg/kg

Flammability and hazard characteristics

It produces acrid smoke after thermal decomposition.

Chemical Properties

white powder


As an inhibitor of molds and other microorganisms in foods, tobacco, pharmaceuticals; in butyl rubber to improve processability and scorching resistance.

Storage Characteristics

Ventilated, low-temperature ,dry storeroom.

Extinguishing agent

Water, carbon dioxide, dry powder, foam


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Company Info

Crovell Biotech (Hebei) Co., Ltd. [China (Mainland)]

Business Type:Manufacturer
City: Shijiazhuang
Province/State: Hebei
Country/Region: China (Mainland)

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